Apomorphine and Alzheimer Aβ: Roles for regulated α cleavage, autophagy, and antioxidation?
نویسندگان
چکیده
منابع مشابه
Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain
BACKGROUND Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been well established in AD animal models in vivo. METHODOLOGY/PRINCIPAL FINDINGS In the present study, APP and presenilin...
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Alzheimer's disease (AD) is a neurodegenerative disease exhibiting amyloid beta (Aβ) peptide accumulation as a key characteristic. Autophagy, which is dysregulated in AD, participates in the metabolism of Aβ. Unexpectedly, we recently found that autophagy, in addition to its degradative function, also mediates the secretion of Aβ. This finding adds Aβ to an increasing number of biomolecules, th...
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The proteolytic processing of Amyloid Precursor Protein (APP) has been linked to sphingolipid-cholesterol microdomains (rafts). However, the raft proteases that may be involved in APP cleavage have not yet been identified. In this work we present evidence that the protease plasmin is restricted to rafts of cultured hippocampal neurons. We also show that plasmin increases the processing of human...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2011
ISSN: 0364-5134
DOI: 10.1002/ana.22359